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Monday, August 3, 2020 | History

1 edition of The water-soluble active principles of ergot found in the catalog.

The water-soluble active principles of ergot

by Barger, George

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Published by Wellcome Physiological Research Laboratories in London .
Written in English

    Subjects:
  • Ergot Alkaloids

  • Edition Notes

    Statementby G. Barger and H.H. Dale
    ContributionsDale, Henry Hallett, 1875-1968, Royal College of Surgeons of England
    The Physical Object
    Pagination2 p. ;
    ID Numbers
    Open LibraryOL26266987M

    Water-soluble chloride, if present in sufficient amount, is capable of initiating or accelerating the corrosion of some metallic materials embedded in or contacting cementitious mixtures such as mortar and concrete. Chloride content, along with other factors, can be indicators for the possibility of corrosion of embedded metallic materials. This test method is used to determine the water.   The active principles of belladonna and opium suppositories, atropine and morphine, are known to enter the fetal circulation. Regular use of opium alkaloids during pregnancy has resulted in addiction of the fetus leading to withdrawal symptoms in the neonate.

    Nerve Ending Active Principle Ergot Alkaloid Nerve Impulse Presidential Address These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. Science 07 Jun Vol. 81, Issue , pp. DOI: /science

    Ergot is a fungus that infects cereal grains, replacing kernels of the fruit with small black masses of mycelium. It produces ergotamine, a potent vasoconstrictor and precursor to LSD. Ergot poisoning (St Anthony's Fire) causes hallucinations, gangrenous loss of limbs, and death.   By making a water infusion of the fungus, Hofmann said, ancient man in Greece could have separated the psychoactive principles from the non-water soluble toxic principles. Hofmann adduced evidence to show that the Greeks were well aware of the psychoactive compounds of ergot, and mentioned that the kykeon was compounded of water, a fragrant.


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Proceedings of a General Court Martial held at the Horse-Guards, on the 24th and 27th of March, 1792, forthe trial of Capt. Richard Powell, Lieut. Christopher Seton, and Lieut. John Hall, ofthe 54th Regiment of Foot; on several charges preferred against them respectively by William Cobbett, late Serjeant-Major of the said Regiment; together with several curious letters which passed between the said William Cobbett and Sir Charles Gould, Judge-Advocate General; and various other documents connected therewith in the order of their dates.

Proceedings of a General Court Martial held at the Horse-Guards, on the 24th and 27th of March, 1792, forthe trial of Capt. Richard Powell, Lieut. Christopher Seton, and Lieut. John Hall, ofthe 54th Regiment of Foot; on several charges preferred against them respectively by William Cobbett, late Serjeant-Major of the said Regiment; together with several curious letters which passed between the said William Cobbett and Sir Charles Gould, Judge-Advocate General; and various other documents connected therewith in the order of their dates.

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The water-soluble active principles of ergot by Barger, George Download PDF EPUB FB2

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Open Library. Featured movies All video latest This Just In Prelinger Archives Democracy Now. Occupy Wall Street TV NSA Clip Library. Ergot and ergotism A monograph based on the Dohme lectures delivered in Johns Hopkins University, Baltimore by George Barger and a great selection of related books, art and collectibles available now at The Water-Soluble Active Principles of Ergot (Journal of Physiology) Barger, G, Dale, H H.

Ergot, fungal disease of cereal grasses, especially rye. The wind carries the fungal spores of ergot to the flowers of susceptible grasses, where the spores germinate, infect, and destroy the ovaries of the an ear of rye infected with ergot, a sweet, yellowish mucus is exuded for a time, followed by a loss of starch as the ear ceases growth.

The ovaries then become permeated by the. The fungus ergot has been employed in medicine for centuries, and the quest for its active principles commenced nearly years ago. The term ergot or Xecale cornutum designates the dark brown, hornshaped pegs, projecting from the ripening ears of rye in place of the rye by: 5.

Ergot Alkaloids Ergotamine Lysergic Acid Ergolines Ergonovine Methylergonovine Indole Alkaloids Dihydroergotamine Pergolide DEAE-Dextran Lisuride Bromocriptine Lysergic Acid Diethylamide Dihydroergotoxine Diuretics, Osmotic Colloids Acetazolamide Thiazides RNA, Ribosomal, 16S DNA, Ribosomal Alphaprodine Dextropropoxyphene Bromazepam Clorazepate.

It is also an ecbolic, causing contraction of the pregnant uterus but, as some assert, inhibiting the contraction of the nonpregnant uterus. Tyramine gives the characteristic color The water-soluble active principles of ergot book for tyrosine. Histamine, β-iminazolyl-ethylamine, the amine derived from histidine, is one of the chief principles of ergot.

It has also been obtained by the. Ergot and ergotism A monograph based on the Dohme lectures delivered in Johns Hopkins University, Baltimore de George Barger et d'autres livres, articles d'art.

Abstract. Ergot occupies a special position among the drugs of our therapeutic armamentarium, not only on account of its unusual classification in the vegetable kingdom but also because of its interesting biological characteristics and the remarkable nature of its active principles.

Alkaloid, any of a class of naturally occurring organic nitrogen-containing bases. Alkaloids have diverse and important physiological effects on humans and other animals. Well-known alkaloids include morphine, strychnine, quinine, ephedrine, and nicotine.

Ergot is a fungal disease very commonly and widely observed on a good number of wild as well as cultivated grasses, and is produced by different species of particular disease is usually characterized by the formation of hard and seedlike ‘ergots’ in place of the normal r, these specific structures are frequently termed as sclerotia, which represent the.

- The chemical composition of ergot is still very imperfectly known, and the active principle (or principles) to which its most important action, that of causing contraction of the uterus, is due, has not been satisfactorily isolated.

The active principles were formerly said to be ergotin and ecbolin, but these do not seem to be pure substances. Ergotinine Citrate is given in doses of to grain hypoder-mically. Secacornin, a solution of the active principles, is given by intramuscular injection in doses of 8 to 15 minims.

Ergotole is given in 5- to minim doses, and may be used hypodermically. Many firms put ergot in. The ergot alkaloids (ergolines) are indole alkaloids and can be divided into two classes:1) The clavine-type alkaloids, which are derivatives of 6,8-dimethylergoline. 2) The lysergic acid derivatives: a) Water soluble ones such as ergometrine and (b) Water insoluble ones such as ergotamine.

Side Effects & Safety Ergot is is a high risk of poisoning, and it can be fatal. Early symptoms of poisoning include nausea, vomiting, muscle pain and weakness, numbness, itching, and.

Ergot (pron. / ˈ ɜːr ɡ ə t / UR-gət) or ergot fungi refers to a group of fungi of the genus Claviceps. The most prominent member of this group is Claviceps purpurea ("rye ergot fungus"). This fungus grows on rye and related plants, and produces alkaloids that can cause ergotism in humans and other mammals who consume grains contaminated with its fruiting structure (called ergot sclerotium).

DALE. and I have thought it better to speak of the action as that of "ergot," and to mention in the body of the paper the particular preparations used.

This seemed the more desirable in view of the possibility that the effects are due, not to one but to twoclosely associated principles. DrG. Bargeris investigating the matter from the chemical side, and in a later joint paper we hope to. From then on, the use of ergot in obstetrics was confined to stopping postpartum hemorrhage (bleeding after childbirth).

It was not until ergot's recognition in various pharmacopoeias during the first half of the nineteenth century that the first steps were taken toward isolating the active principles of the drug. If these substances are really the active principles of ergot, it becomes evident why it is not admissible to remove gummy and albuminous matter by the addition of an excess of strong alcohol.

In this connection see the interesting papers by C. Lewis Diehl, and by Prof. Hallberg, in. Ergot is a parasitic fungus (Claviceps purpurea) which grows on rye (Secale cornutum or cereale) and occasionally on other kinds of grains, more rarely on other occurrence on one of the breadcereal grains explains why it has so frequently given rise to wide-spread epidemics of poisoning and thus acquired a considerable prominence in toxicology.

Solubility is the property of a solid, liquid or gaseous chemical substance called solute to dissolve in a solid, liquid or gaseous solubility of a substance fundamentally depends on the physical and chemical properties of the solute and solvent as well as on temperature, pressure and presence of other chemicals (including changes to the pH) of the solution.

When ergot first contaminates a head of rye, the rye will spew out yellow-colored mucus, often called "honeydew", which contains the fungal spores.

The fungal spores land on other heads of rye, infecting each head that a spore touches. This is how ergot spreads. Ergot poisoning affects the nervous system.development of ergot research, that which began somewhere around the year with the isolation and preparation in a pure state of the first homogeneous ergot alkaloid, ergotamine.

The idea that the active principles of ergot are al- kaloids only began to find .The psychotomimetic principles that we isolated proved to be Iysergic acid derivatives, Iysergic acid amides and other ergot alkaloids.

Thus in this strange Mexican drug we met with old friends, since Iysergic acid derivatives and ergot alkaloids had been favorite subjects of research in our laboratory since the time I had first synthesized LSD.